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FC LAB (Chow Lab) We are part of the HTI Microbe Lab!
PRIMARY RESEARCH AREAS
Cross-kingdom RNAi between host and pathogen
Small RNAs such as miRNAs, siRNAs are part of the RNA interference (RNAi). Our laboratory is currently pioneering research on Cross-kingdom RNA interference (RNAi) between host and pathogen. This fascinating biological phenomenon involves the transfer of RNA molecules from a host organism to a pathogen, or vice versa, to manipulate gene expression and influence the outcome of their interactions. Our studies are particularly focused on understanding how this process plays a crucial role in disease progression, and how it can be exploited to develop innovative diagnostic and therapeutic strategies.
One health
Our lab's philosophy also aligns with the "One Health" concept, which recognises that the health of people is closely connected to the health of animals and our shared environment. This interdisciplinary approach is crucial in the face of shared health threats at the human-animal-environment interface. For instance, many emerging infectious diseases in humans originate from animals, and environmental changes can influence the spread of these diseases. Our research incorporates a "One Health" perspective to understand and combat diseases that impact multiple species. We believe that by breaking down disciplinary silos and fostering a collaborative, holistic approach, we can develop more effective strategies for predicting, preventing, and responding to health issues. "One Health" is not just a concept, but a practical framework for action that enhances health security, improves public health, and ensures a better future for our planet.
Extracellular vesicles in microbes and infectious diseases
Our research also delves deeply into the realm of extracellular vesicles (EVs), small membrane-bound particles secreted by cells, in the context of microbes and infectious diseases. Emerging evidence points to the significant role of these vesicles in microbial communication, pathogenesis, and defense mechanisms. For instance, bacteria, fungi, and virus-infected cells use EVs to transport a variety of biomolecules such as proteins, lipids, and nucleic acids, influencing host-pathogen interactions, disease outcomes or even induce drug resistance. Furthermore, these vesicles can modulate the host immune response, aiding the microbe's survival and propagation. Our work is focused on deciphering the intricate roles of microbial EVs in disease progression and leveraging this knowledge to develop innovative EV-based diagnostic, therapeutic strategies and their mechanism.
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